Principal Scientist I, Analytics & Separation Specialist, Oligonucleotide Research
Company: F. Hoffmann-La Roche Gruppe
Location: Pleasanton
Posted on: November 9, 2024
Job Description:
Roche fosters diversity, equity and inclusion, representing the
communities we serve. When dealing with healthcare on a global
scale, diversity is an essential ingredient to success. We believe
that inclusion is key to understanding people's varied healthcare
needs. Together, we embrace individuality and share a passion for
exceptional care. Join Roche, where every voice matters.The
PositionWe advance science so that we all have more time with the
people we love.Roche Diagnostics is looking for a highly motivated
and skilled Principal Scientist, Analytics & Separation Specialist
in Oligonucleotide Research (Scientist) to support the development
of advanced molecular diagnostics technologies. This role involves
hands-on expertise in preparative chromatography and analytical
techniques throughout the product development lifecycle, from early
research to on-market support. As part of the Chemistry Team, you
will have access to cutting-edge technologies and state-of-the-art
instrumentation, enabling you to contribute meaningfully to
advancements in molecular diagnostics. Your work will directly
impact global health, pushing the boundaries of what's possible in
the field of diagnostics.Key Responsibilities:
- You have demonstrated experience purifying, analyzing, and
characterizing complex oligonucleotides and related analogs.
- You have the ability to develop innovative analytical methods
for reagents and assay performance, applicable in R&D and
Operations; supporting scale-up and launch efforts.
- You have the ability to design and execute advanced
troubleshooting experiments in coordination with collaborators;
demonstrated experience developing creative assays to understand
and detect system defects.
- You have the ability to support documentation transfer,
specifically of prototype methods and documentation from research
to development and manufacturing.
- You will serve as a subject matter expert and provide expertise
across R&D departments (oligo synthesis & purification, assay
development) and operations.This position is based on-site in
Pleasanton, CA.Relocation benefits are not offered for this
role.Who You Are:(Requirements)
- You have a Bachelor's or Master's Degree (preferred) in
Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or
related field) with 7+ years of industry experience; or a Ph.D.
with 3+ years of relevant industry experience in Chemistry,
Biochemistry, Chemical Biology, Medical Chemistry (or related
field).
- You have comprehensive experience and problem-solving skills in
UPLC/HPLC, ion pair chromatography, ion exchange, mass
spectrometry, absorption, and fluorescence spectroscopy.
- You are proficient in oligonucleotide purification and
characterization.
- You have demonstrated experience in DNA, RNA, non-natural
modifications, and dye-modifications; you demonstrated experience
in designing and optimizing analytical assays.
- You have demonstrated communication and organizational skills,
including technical writing skills for detailed
documentation/report preparation; excellent verbal and written
communication skills for effective team collaboration.Preferred:
- You have proficiency organizing and maintaining a research
laboratory.
- You have experience with automated DNA synthesis,
phosphoramidite chemistry, and click-chemistry.
- You have working knowledge of PCR and/or other amplification
technologies.This position is based on-site in Pleasanton,
CA.Relocation benefits are not offered for this role.The expected
salary range for this position based on the primary location of
Pleasanton, CA is $93,800 - $202,500. Actual pay will be determined
based on experience, qualifications, geographic location, and other
job-related factors permitted by law. A discretionary annual bonus
may be available based on individual and Company performance.This
position also qualifies for the benefits detailed at the link
provided below.[]Who we areAt Roche, more than 100,000 people
across 100 countries are pushing back the frontiers of healthcare.
Working together, we've become one of the world's leading
research-focused healthcare groups. Our success is built on
innovation, curiosity and diversity.Roche is an equal opportunity
employer and strictly prohibits unlawful discrimination based upon
an individual's race, color, religion, gender, sexual orientation,
gender identity/expression, national origin/ancestry, age,
mental/physical disability, medical condition, marital status,
veteran status, or any other characteristic protected by law.If you
have a disability and need an accommodation in relation to the
online application process, please contact us by completing this
form .
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Keywords: F. Hoffmann-La Roche Gruppe, Merced , Principal Scientist I, Analytics & Separation Specialist, Oligonucleotide Research, Other , Pleasanton, California
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